Major Home Issues:
- Lack of iTunes support on Linux. I've tried the Ubuntu One music store, Amazon, etc. and they just don't measure up... at least not yet.
- Support for Linux in web conferencing solutions such as Web-Ex, Citrix, etc.
- Open Office file compatibility with Microsoft Office. Generally the files are always readable, however formatting can get a bit screwy, particularly if you are dealing with change tracking and more advanced document formatting. I've found saving documents in Microsoft Word 97/2000/XP format within Open Office to be the most compatible with Microsoft users.